The N-S avenues in central Amarillo are named for the presidents of the United States in order of when they served, from Washington just west of downtown through Cleveland to the east. Most of the E-W avenues are numbered, from N 24th through S 58th.
Old Route 66 crosses east to west through Amarillo, named Amarillo Boulevard. It passes just to the north of the airport, downtown, and the medical center, connecting US-60 on the east side with I-40 on the west side.
Loop 335 has been designated, but has not yet been developed into a limited access loop as in other cities. It comprises Soncy Road on the west near Westgate Mall, St. Francis Avenue on the north, Hollywood Road on the south, and Lakeside Drive on the east near the airport.
